A cache includes an upstream port, a cache memory for storing cache lines each having a line width, and a cache controller. The cache controller is coupled to the upstream port and the cache memory. The upstream port transfers data words having a transfer width less than the line width. In response to a cache line fill, the cache controller selectively determines data bus inversion information for a sequence of data words having the transfer width, and stores the data bus inversion information along with selected inverted data words for the cache line fill in the cache memory.