![1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)](/docs/US/2023-05-25/US20230159521A1/abs.jpg.600x600.jpg)
- 专利标题： 1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)
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申请号： US17916405申请日： 2021-04-02
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公开(公告)号： US20230159521A1公开(公告)日： 2023-05-25
- 发明人: Simon GIROUX , Philippe Marcel NUHANT , Upul Keerthi BANDARAGE , Pedro Manuel GARCIA BARRANTES , Yusheng LIAO , Zachary GALE-DAY , Wenxin GU , Alexander S. KARNS , Hu ZHANG , Emily Elizabeth ALLEN , Jinwang XU , Michael Paul DENINNO , Qing TANG , Diane Marie BOUCHER , Lev T.D. FANNING , Amy B. HALL , Dennis James HURLEY , Mac Arthur JOHNSON, Jr. , John Patrick MAXWELL , Rebecca Jane SWETT , Timothy Lewis TAPLEY , Stephen A. THOMSON , Veronique DAMAGNEZ , Kevin Michael COTTRELL
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US2021/025616 2021.04.02
- 进入国家日期： 2022-09-30
- 主分类号： C07D471/04
- IPC分类号： C07D471/04
![1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)](/abs-image/US/2023/05/25/US20230159521A1/abs.jpg.150x150.jpg)
摘要：
1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).
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