A tire pressure detection system with single antenna includes a detection end 10 and a receiving end. The detection end includes tire pressure detectors to detect the tire to obtain the tire status. The tire pressure detectors outputs the tire status, and the information of the tire status is output in the form of radio frequency signal and Bluetooth signal to the tire-pressure receiving device, the audio-video device and the mobile device so that the users are acknowledged about the information of the tire including tire pressure and tire temperature.