Aspects and embodiments relate to a method and apparatus configured to perform that method. The method relates to generating an indication of relevance associated with a selected biological phenomenon indicative of condition of an immune system of a patient, that selected biological phenomenon being associated with response of a patient to a chosen therapy. The method comprises steps of: determining one or more measurable input parameters characteristic of the patient and associated with the biological phenomenon; mapping the one or more input parameters to a contribution to a score associated with the selected biological phenomenon; and combining the mapped contributions across the one or more input parameters to calculate the score associated with the selected biological phenomenon. A decision support system in accordance with aspects and embodiments may be configured to provide a score and/or visualisation, for example, a numerical value or graphical representation, relating to one or more underlying biological phenomena contributing to immune response or immune condition of a patient to a therapy. The underlying biological phenomena may be quantified using various biomarkers and/or measurable input parameters.