Invention Application
- Patent Title: TLR3 AGONIST FOR USE FOR INDUCING APOPTOSIS IN SENESCENT CANCER CELLS
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Application No.: US16348775Application Date: 2017-11-10
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Publication No.: US20190292546A1Publication Date: 2019-09-26
- Inventor: Serge LEBECQUE , Toufic RENNO , Béatrice VANBERVLIET , Yann ESTORNES
- Applicant: Centre Léon-Bérard , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre national de la recherche scientifique , Université Claude Bernard Lyon 1 , HOSPICES CIVILS DE LYON
- Priority: EP16306475.1 20161110
- International Application: PCT/EP2017/078944 WO 20171110
- Main IPC: C12N15/117
- IPC: C12N15/117 ; C12N5/09 ; A61K31/337 ; A61N5/10
Abstract:
The present invention relates to a TLR3 agonist for use for inducing apoptosis in senescent cancer cells, in particular to a TLR3 agonist for use as a medicament for inducing apoptosis in senescent cancer cells. In particular, it relates to a TLR3 agonist for use for the treatment of cancer, optionally in combination with a chemotherapeutic agent or with radiotherapy. It further relates to a pharmaceutical composition comprising a TLR3 agonist and a chemotherapeutic agent.
Information query
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