Invention Application
- Patent Title: HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS
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Application No.: US16314574Application Date: 2016-06-23
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Publication No.: US20190292191A1Publication Date: 2019-09-26
- Inventor: John V. Duncia , Daniel S. Gardner , John Hynes , John E. Macor , Natesan Murugesan , Joseph B. Santella , Hong Wu , Durgarao Kantheti , Satheesh Kesavan Nair , Venkatram Reddy Paidi , Sreekantha Ratna Kumar , Kandhasamy Sarkunam , Ramesh Kumar Sistla , Subba Rao Polimera
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Priority: IN1876/DEL/15 20150624
- International Application: PCT/US16/38861 WO 20160623
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D471/04 ; C07D413/04 ; C07D401/14

Abstract:
Disclosed are compounds of Formula (I) Formula (I) or salts thereof, wherein HET is a heteroaryl selected from oxazolyl, pyrazolyl, imidazo[1,2-b]pyridazin-3-yl, and pyrazolo[1,5-a]pyrimidin-3-yl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a carbon ring atom in the heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb; and R1, R3, and Rb are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.
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