The present invention is directed to a therapeutic method of treatment of uremia associated with renal dysfunction long after transplant, comprising administering to a subject in need a therapeutically effective amount of a Chinese medicine composition. The Chinese medicine composition is the extract of the mixture including Fructus corni, radix Rehmanniae, rhizoma Dioscoreae, Radix Angelica sinensis, Cortex eucommiae, Semen cuscutae, Fructus lycii, Fructus Cinnamomum cassia, Radix aconiti lateralis preparata, Rhizoma Zingiberis, Poria, Phelloendron amurense Cortex, radix Achyranthis Bidentatae, and Atractylodes Lancea Rhizoma.