A method and system of assessing and monitoring of cardiopulmonary diseases can include the steps of receiving a composite signal representative of individual events from a plurality of sources associated with a patients cardio-pulmonary system and separating an individual signal as a separate component of the composite signal where the individual signal i s representative of an individual event from one of a plurality of cardio-pulmonary events. The method and system can further include and deriving clinical findings responsive from the separating and presenting the clinical findings.