The purpose of the present invention is to provide a control device for an internal combustion engine with which it is possible to favorably control an engine even if there could occur a difference in temperatures of fuel injected into respective cylinders. The present invention is a control device for an internal combustion engine, for controlling an internal combustion engine provided with fuel injection valves for directly injecting fuel respectively to a plurality of cylinders, wherein: the control device is provided with a fuel temperature acquiring means for acquiring respective temperatures of fuel injected to each of the cylinders; and at least one of a fuel injection valve control amount, ignition control amount, and intake and exhaust valve control amount of each of the cylinders is set in accordance with the respective temperatures of fuel acquired by the fuel temperature acquiring means. Alternatively, the present invention is a control device for an internal combustion engine, for controlling an internal combustion engine provided with fuel injection valves for directly injecting fuel respectively to a plurality of cylinders, wherein the control device is provided with a valve-closing time detecting means for detecting a valve-closing time of a valve body of each of the fuel injection valves, and a fuel temperature estimating means for estimating the temperature of fuel on the basis of the valve-closing duration of the valves detected by the valve-closing time detecting means.