Disclosed is a pharmaceutical composition for the treatment of Depression, wherein the pharmaceutical composition is comprised of the following herbs in weight parts: 2-10 parts Ramulus Cinnamomi, 2-10 parts Rhizoma Zingiberis, 2-10 parts Fructus Schisandrae Chinensis, 2-8 parts Semen Ziziphi Spinosae, 2-8 parts Radix Codonopsis, 1-3 parts Rhizoma Dioscoreae, 0.5-2.5 parts Flos Inulae, 1-3 parts Caulis Bambusae in Taenia, 1-3 parts Fructus Trichosanthis, 1.5-4 parts Caulis Polygoni Multiflori, 1.5-4 parts Radix Ophiopogonis, 2-8 parts Radix Rehmanniae, 1.5-4 parts Cortex Moutan Radicis, 0.5-2.5 parts Fructus Gardeniae, 0.5-2.5 parts Herba Lophatheri, and 0.2-1.5 parts Folium Sennae. Also disclosed is a method for preparing the pharmaceutical composition as described above for treatment of depression.