Some demonstrative embodiments include devices, systems and/or methods of processing Packet Data Convergence Protocol (PDCP) Protocol Data Units (PDUs) of an Evolved Universal Mobile Telecommunications System (UMTS) Terrestrial Radio Access Network (E-UTRAN) Radio Access Bearer (E-RAB). For example, an apparatus may include PDCP processor configured to process a plurality of PDUs of an E-RAB, the PDCP processor configured to apply a sequence of a plurality of PDCP procedures to one or more first PDUs communicated via the cellular link, and to apply no more than a part of the sequence of PDCP procedures, by selecting not to apply one or more of the plurality of PDCP procedures, to one or more second PDUs communicated via a non-cellular Radio Access Technology (RAT).