Invention Application
- Patent Title: RECOMBINANT CO-EXPRESSION OF VITAMIN K EPOXIDE REDUCTASE SUBUNIT 1 TO IMPROVE VITAMIN K DEPENDENT PROTEIN EXPRESSION
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Application No.: US15409032Application Date: 2017-01-18
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Publication No.: US20170226487A1Publication Date: 2017-08-10
- Inventor: Friedrich Scheiflinger , Ernst Boehm
- Applicant: Baxalta GmbH , Baxalta Incorporated
- Applicant Address: CH Glattpark (Opfikon) US IL Bannockburn
- Assignee: Baxalta GmbH,Baxalta Incorporated
- Current Assignee: Baxalta GmbH,Baxalta Incorporated
- Current Assignee Address: CH Glattpark (Opfikon) US IL Bannockburn
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N9/64
Abstract:
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems.
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