发明申请
US20160319370A1 TET2 AS A DIAGNOSTIC AND PRONOSTIC MARKER IN HEMATOPOIETIC NEOPLASMS
审中-公开
TET2作为HEMATOPOIETIC NEOPLASMS中的诊断和诊断标记
- 专利标题： TET2 AS A DIAGNOSTIC AND PRONOSTIC MARKER IN HEMATOPOIETIC NEOPLASMS
- 专利标题（中）： TET2作为HEMATOPOIETIC NEOPLASMS中的诊断和诊断标记
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申请号： US15177055申请日： 2016-06-08
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公开(公告)号： US20160319370A1公开(公告)日： 2016-11-03
- 发明人: Franck Viguie , Olivier Bernard , Michaela Fontenay , Christian Bastard , Francois Delhommeau , William Vainchenker
- 申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT GUSTAVE-ROUSSY , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS , CENTRE HENRI BECQUEREL , UNIVERSITE PARIS DESCARTES , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , UNIVERSITE PARIS-SUD
- 申请人地址： FR Paris Cedex FR Villejuif FR Paris FR Rouen FR Paris FR Paris FR Orsay
- 专利权人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),INSTITUT GUSTAVE-ROUSSY,ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS,CENTRE HENRI BECQUEREL,UNIVERSITE PARIS DESCARTES,UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6),UNIVERSITE PARIS-SUD
- 当前专利权人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),INSTITUT GUSTAVE-ROUSSY,ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS,CENTRE HENRI BECQUEREL,UNIVERSITE PARIS DESCARTES,UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6),UNIVERSITE PARIS-SUD
- 当前专利权人地址： FR Paris Cedex FR Villejuif FR Paris FR Rouen FR Paris FR Paris FR Orsay
- 优先权： EP08305255.5 20080612; EP09155169.7 20090313
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A61K31/7068
摘要：
The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.
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