Invention Application
- Patent Title: PHARMACOLOGICALLY ACTIVE COMPOUNDS
- Patent Title (中): 药物活性化合物
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Application No.: US15107653Application Date: 2014-12-23
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Publication No.: US20160318947A1Publication Date: 2016-11-03
- Inventor: Martin Leuwer , Paul O'Neill , Neil Berry , Chandrakala Pidathala
- Applicant: THE UNIVERSITY OF LIVERPOOL
- Applicant Address: GB Liverpool
- Assignee: The University of Liverpool
- Current Assignee: The University of Liverpool
- Current Assignee Address: GB Liverpool
- Priority: GB1322905.9 20131223
- International Application: PCT/GB2014/053838 WO 20141223
- Main IPC: C07D491/107
- IPC: C07D491/107 ; C07D211/06 ; C07D205/04 ; C07D295/192 ; C07D265/30

Abstract:
The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
Public/Granted literature
- US09676786B2 Pharmacologically active compounds Public/Granted day:2017-06-13
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