Invention Application
US20160287717A1 Core and Surface Modification of Mesoporous Silica Nanoparticles to Achieve Cell Specific Targeting In Vivo.
审中-公开
介孔二氧化硅纳米颗粒的核心和表面改性以实现细胞特异性靶向靶向。
- Patent Title: Core and Surface Modification of Mesoporous Silica Nanoparticles to Achieve Cell Specific Targeting In Vivo.
- Patent Title (中): 介孔二氧化硅纳米颗粒的核心和表面改性以实现细胞特异性靶向靶向。
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Application No.: US15023093Application Date: 2014-09-18
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Publication No.: US20160287717A1Publication Date: 2016-10-06
- Inventor: Charles Jeffrey Brinker , Jason TOWNSON , Yu-Shen LIN , Paul N. DURFEE
- Applicant: STC.UNM , SANDIA CORPORATION
- International Application: PCT/US2014/056312 WO 20140918
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K9/51
Abstract:
In one aspect, the invention provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit single cell binding specificity to the substantial exclusion of non-targeted cells. For example, MSNPs and protocells of the invention may be used to target specific delivery of therapeutic agents to cancer cells or to specific blood vessel types (e.g. in the arterial, venous and/or capillary vessels or any combination of vessels). Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.
Information query
