Invention Application
- Patent Title: NEPRILYSIN INHIBITORS
- Patent Title (中): NEPRILYSIN抑制剂
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Application No.: US14460567Application Date: 2014-08-15
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Publication No.: US20150133658A1Publication Date: 2015-05-14
- Inventor: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
- Applicant: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
- Applicant Address: US CA South San Francisco
- Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D249/10 ; C07D231/14 ; C07D261/12 ; C07D239/34 ; C07D249/04 ; C07D249/18

Abstract:
In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US09487514B2 Neprilysin inhibitors Public/Granted day:2016-11-08
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