发明申请
US20140377386A1 PLANT-BASED INHIBITORS OF KETOHEXOKINASE FOR THE SUPPORT OF WEIGHT MANAGEMENT
审中-公开
用于支持体重管理的基于植物药物的KETOHEXOKINASE抑制剂
- 专利标题： PLANT-BASED INHIBITORS OF KETOHEXOKINASE FOR THE SUPPORT OF WEIGHT MANAGEMENT
- 专利标题（中）： 用于支持体重管理的基于植物药物的KETOHEXOKINASE抑制剂
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申请号： US14305876申请日： 2014-06-16
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公开(公告)号： US20140377386A1公开(公告)日： 2014-12-25
- 发明人: Jatinder Rana , Russell Keith Randolph , Jeffrey Scholten , MyPhuong Thi Le , Richard J. Johnson , Miguel Angel Lanaspa Garcia
- 申请人： Jatinder Rana , Russell Keith Randolph , Jeffrey Scholten , MyPhuong Thi Le , Richard J. Johnson , Miguel Angel Lanaspa Garcia
- 申请人地址： US MI Ada US CO Denver
- 专利权人： Access Business Group International LLC,The Regents of the University of Colorado
- 当前专利权人： Access Business Group International LLC,The Regents of the University of Colorado
- 当前专利权人地址： US MI Ada US CO Denver
- 主分类号： A61K36/73
- IPC分类号： A61K36/73 ; A61K36/38 ; A61K36/185 ; A61K36/487 ; A61K36/539 ; A61K36/12 ; A61K36/19 ; A61K36/62 ; A61K36/75 ; A61K36/23 ; A61K36/605 ; A61K36/232 ; A61K36/44
摘要：
A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 μg/mL to about 1000 μg/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may include administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 μg/mL to about 1000 μg/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.
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