Invention Application
- Patent Title: LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL
- Patent Title (中): 长期存在于细胞周期中的长波长荧光细胞离子指示器
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Application No.: US14302175Application Date: 2014-06-11
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Publication No.: US20140363839A1Publication Date: 2014-12-11
- Inventor: Kyle GEE , Vladimir MARTIN
- Applicant: Kyle GEE , Vladimir MARTIN
- Applicant Address: US CA Carlsbad
- Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee Address: US CA Carlsbad
- Main IPC: G01N33/58
- IPC: G01N33/58 ; C09B11/24
Abstract:
Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups.
Public/Granted literature
- US09341631B2 Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol Public/Granted day:2016-05-17
Information query
IPC分类:
