发明申请
- 专利标题: CHROMATOGRAPH MASS SPECTROMETRY DATA PROCESSING APPARATUS
- 专利标题(中): 色谱质谱数据处理设备
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申请号: US14177302申请日: 2014-02-11
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公开(公告)号: US20140303903A1公开(公告)日: 2014-10-09
- 发明人: Yuichiro FUJITA , Shigeki KAJIHARA
- 申请人: SHIMADZU CORPORATION
- 申请人地址: JP Kyoto-shi
- 专利权人: SHIMADZU CORPORATION
- 当前专利权人: SHIMADZU CORPORATION
- 当前专利权人地址: JP Kyoto-shi
- 优先权: JP2013-078428 20130404
- 主分类号: H01J49/00
- IPC分类号: H01J49/00
摘要:
Even when only mass spectra wherein the reproducibility of peak intensities is low are obtained in a mass spectrometry apparatus using, for example, a MALDI ion source, the correction of shifts in retention time using TICs for a plurality of specimens is performed with good precision. For each mass spectrum, variable scaling is executed which combines such first scaling as to equalize the extent of variations in signal intensity values in one mass spectrum, among different mass spectra, and second scaling for performing weighting according to relative variations in signal intensity values for each mass spectrum (S3). The signal intensity values after the scaling are added to obtain a total signal intensity value for one measurement time point (S4). From a plurality of total signal intensity values thus obtained, a TIC is created (S6). Using these TICs, RT alignment is executed (S8). Thus, the similarity in TIC waveforms increases, and RT alignment can be suitably performed.
公开/授权文献
- US09472386B2 Chromatograph mass spectrometry data processing apparatus 公开/授权日:2016-10-18
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