Invention Application
US20140134737A1 Alternative Splicing Modulators and Splice Variants and Their Use in the Control and Detection of Pluripotency and Differentiation
审中-公开
可选的拼接调制器和接头变体及其在多能性和分化的控制和检测中的应用
- Patent Title: Alternative Splicing Modulators and Splice Variants and Their Use in the Control and Detection of Pluripotency and Differentiation
- Patent Title (中): 可选的拼接调制器和接头变体及其在多能性和分化的控制和检测中的应用
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Application No.: US14128052Application Date: 2012-06-29
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Publication No.: US20140134737A1Publication Date: 2014-05-15
- Inventor: Benjamin J. Blencowe , Mathieu Gabut , Hong Han
- Applicant: Benjamin J. Blencowe , Mathieu Gabut , Hong Han
- Applicant Address: CA ON Toronto
- Assignee: Governing Council of the University of Toronto
- Current Assignee: Governing Council of the University of Toronto
- Current Assignee Address: CA ON Toronto
- International Application: PCT/CA2012/000616 WO 20120629
- Main IPC: C12N5/074
- IPC: C12N5/074
Abstract:
Nucleotide sequences encoding novel splice variants of FOXP1, proteins encoded by the novel splice variants and antibodies thereto are disclosed. In addition, methods are described for maintaining a population of homogenous self-renewing and pluripotent stem cells, suppressing stem cell differentiation, and reprogramming somatic cells into pluripotent stem cells comprising the use of the novel splice variants. Also disclosed are modulators of alternative splicing such as MBNL1 and MBNL2 and methods and uses thereof for promoting pluripotency.
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