A diagnostic factor set determination apparatus and method is provided. The diagnostic factor set determination apparatus includes a personal examination data acquiring unit configured to acquire personal examination data including a plurality of diagnostic factors, a disease model selecting unit configured to select a disease model that includes one or more of the plurality of diagnostic factors, and a diagnostic factor processing unit configured to determine a diagnostic factor set according to a sum of disease weights of a first group of the plurality of diagnostic factors that is not in the selected disease model.