发明申请
- 专利标题： Human Adam-10 Inhibitors
- 专利标题（中）： 人类Adam-10抑制剂
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申请号： US13541503申请日： 2012-07-03
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公开(公告)号： US20130144056A1公开(公告)日： 2013-06-06
- 发明人: Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
- 申请人： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
- 申请人地址： US MD Rockville
- 专利权人： SYMPHONY EVOLUTION, INC.
- 当前专利权人： SYMPHONY EVOLUTION, INC.
- 当前专利权人地址： US MD Rockville
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; C07D403/06 ; C07D401/06 ; C07D413/06
摘要：
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
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