Invention Application
US20120288855A1 Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use
审中-公开
对双链DNA具有高选择性的荧光化学化合物及其使用方法
- Patent Title: Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use
- Patent Title (中): 对双链DNA具有高选择性的荧光化学化合物及其使用方法
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Application No.: US13559300Application Date: 2012-07-26
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Publication No.: US20120288855A1Publication Date: 2012-11-15
- Inventor: Jolene A. Bradford , Ching-Ying Cheung , Shih-Jung Huang , Patrick R. Pinson , Stephen T. Yue
- Applicant: Jolene A. Bradford , Ching-Ying Cheung , Shih-Jung Huang , Patrick R. Pinson , Stephen T. Yue
- Applicant Address: US CA Carlsbad
- Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee Address: US CA Carlsbad
- Main IPC: G01N21/76
- IPC: G01N21/76 ; C07D417/14 ; C07D413/06 ; C07D417/06
Abstract:
Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
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