发明申请
- 专利标题： INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS
- 专利标题（中）： FILOVIRUS进入宿主细胞的抑制剂
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申请号： US13383345申请日： 2010-07-10
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公开(公告)号： US20120189614A1公开(公告)日： 2012-07-26
- 发明人: Arnab Basu , Debra M. Mills , Norton P. Peet , John D. Williams
- 申请人： Arnab Basu , Debra M. Mills , Norton P. Peet , John D. Williams
- 申请人地址： US MA Worcester
- 专利权人： Crobiotix, Inc.
- 当前专利权人： Crobiotix, Inc.
- 当前专利权人地址： US MA Worcester
- 国际申请： PCT/US10/41632 WO 20100710
- 主分类号： A61K31/4706
- IPC分类号： A61K31/4706 ; C07C255/40 ; C07D491/22 ; C07D405/06 ; C07D307/72 ; C07D471/04 ; C07D243/12 ; C07D213/74 ; C07C317/50 ; C07D249/12 ; A61P31/14 ; A61P25/00 ; A61P37/04 ; A61P35/00 ; A61K39/395 ; A61K38/18 ; A61P25/20 ; A61K31/277 ; A61K31/4375 ; A61K31/517 ; A61K31/345 ; A61K31/437 ; A61K31/551 ; A61K31/4406 ; A61K31/167 ; A61K31/4196 ; C07D215/40
摘要：
Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.
公开/授权文献
- US09101635B2 Inhibitors of filovirus entry into host cells 公开/授权日：2015-08-11
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