发明申请
- 专利标题: COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS
- 专利标题(中): 用于测序核酸的组合物和方法
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申请号: US13117565申请日: 2011-05-27
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公开(公告)号: US20110300534A1公开(公告)日: 2011-12-08
- 发明人: Chung-Fan Chiou , Chao-Chi Pan , Jenn-Yeh Fann , Shang-Chia Chang , Tsu-Ju Fu
- 申请人: Chung-Fan Chiou , Chao-Chi Pan , Jenn-Yeh Fann , Shang-Chia Chang , Tsu-Ju Fu
- 申请人地址: TW Chutung
- 专利权人: Industrial Technology Research Institute
- 当前专利权人: Industrial Technology Research Institute
- 当前专利权人地址: TW Chutung
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C07H21/04
摘要:
Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing.
公开/授权文献
- US09670243B2 Compositions and methods for sequencing nucleic acids 公开/授权日:2017-06-06
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