A method and system for fabricating a dental prosthesis are provided. High resolution digital scanned images of a patient's oral structures are acquired. Three dimensional (3D) cone beam X-ray images of hard and soft oral tissues are acquired. The scanned images are integrated with the 3D cone beam X-ray images in a 3D space to obtain combined three dimensional images of the oral structures. The occlusal relationship between upper and lower oral structures are digitally simulated using the combined three dimensional images. The dental prosthesis is digitally modeled for planning intra-oral positioning and structure of the dental prosthesis. The digital dental prosthesis model is refined based on simulated force tests performed for assessing interference and retention of the digital dental prosthesis model. A prospective dental prosthesis model is created based on the refined digital dental prosthesis model. The dental prosthesis is fabricated based on a verified prospective dental prosthesis model.