发明申请
- 专利标题： Method
- 专利标题（中）： 方法
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申请号： US13128813申请日： 2009-11-11
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公开(公告)号： US20110269826A1公开(公告)日： 2011-11-03
- 发明人: Susan M. Kingsman , Alan J. Kingsman , Scott Ralph , Kyriacos A. Mitrophanous , Stephane Palfi , Bechir Jarraya
- 申请人： Susan M. Kingsman , Alan J. Kingsman , Scott Ralph , Kyriacos A. Mitrophanous , Stephane Palfi , Bechir Jarraya
- 申请人地址： UK Oxford
- 专利权人： OXFORD BIOMEDICA (UK) LIMITED
- 当前专利权人： OXFORD BIOMEDICA (UK) LIMITED
- 当前专利权人地址： UK Oxford
- 优先权： GB0820628.6 20081111; GB0917241.2 20091001
- 国际申请： PCT/GB2009/002645 WO 20091111
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61P25/14 ; A61P25/16
摘要：
The present invention provides methods for: (i) treating and/or preventing Parkinson's disease in a subject without causing cognitive impairment by using dopamine replacement gene therapy to maintain or restore constant physiological dopaminergic tone in both the dorsal and ventral striatum of the subject; (ii) normalising neuronal electrical activity in basal ganglia and/or subthalamic nucleus in a Parkinson's disease subject; and (iii) treating and/or preventing dyskinesias associated with oral L-dopa administration in a Parkinson's disease subject by administration of a vector system for dopamine replacement gene therapy to the subject.
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