发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR DETECTING DEACETYLASE ACTIVITY
- 专利标题（中）： 检测脱乙酰酶活性的组合物和方法
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申请号： US13082265申请日： 2011-04-07
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公开(公告)号： US20110251104A1公开(公告)日： 2011-10-13
- 发明人: Can Ozbal , William LaMarr
- 申请人： Can Ozbal , William LaMarr
- 主分类号： C40B30/10
- IPC分类号： C40B30/10 ; C12Q1/34
摘要：
A method for the quantitative determination of the activity of enzymes in the Sirtuin family through the quantification of the acetyl-ADPr product that is formed is provided. The method described allows for a wide range of substrates, including peptides, intact proteins, or protein complexes (e.g. nucleosomes) to be used as substrates without the need for additional analytical methods to be developed.
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