Invention Application
- Patent Title: Modulation of T cell Differentiation for the treatment of T helper cell mediated diseases
- Patent Title (中): 调节T细胞分化治疗T辅助细胞介导的疾病
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Application No.: US12437452Application Date: 2009-05-07
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Publication No.: US20110097325A1Publication Date: 2011-04-28
- Inventor: Frederic J. de Sauvage , Iqbal Grewal , Austin L. Gurney
- Applicant: Frederic J. de Sauvage , Iqbal Grewal , Austin L. Gurney
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12N5/0783 ; A61K31/7105 ; A61K38/00 ; G01N33/53 ; A61K31/711 ; A61P37/02 ; A61P31/04 ; A61P31/10
Abstract:
The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype, based on the relative expression levels of the gene TCCR, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.
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