Cross-talk is canceled in a cooperative wireless relay network that includes a base station (BS), a relay station (RS), and a mobile station (MS). A coupling channel between a transmit antenna and a receive antenna colocated at the RS is estimated. Cross-talk interference determination is based on a previous transmitted signal by the transmit antenna, and the coupling channel. The cross-talk interference is subtracted from a currently received signal by the receive antenna to obtain a residual signal. The residual signal is then transmitted as a next transmitted signal by the transmit antenna.