发明申请
US20100280243A1 PROCESS FOR PRODUCTION OF 4- (SUBSTITUTED PHENYL) HEXAHYDROPYRIDO [2,1-C] [1,4] OXAZIN-6-ONE
审中-公开
制备4-（取代苯基）十六氢化二[2,1-C] [1,4]氧杂-6-酮的方法
![PROCESS FOR PRODUCTION OF 4- (SUBSTITUTED PHENYL) HEXAHYDROPYRIDO [2,1-C] [1,4] OXAZIN-6-ONE](/docs/US/2010-11-04/US20100280243A1/abs.jpg.600x600.jpg)
- 专利标题： PROCESS FOR PRODUCTION OF 4- (SUBSTITUTED PHENYL) HEXAHYDROPYRIDO [2,1-C] [1,4] OXAZIN-6-ONE
- 专利标题（中）： 制备4-（取代苯基）十六氢化二[2,1-C] [1,4]氧杂-6-酮的方法
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申请号： US12810783申请日： 2008-12-25
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公开(公告)号： US20100280243A1公开(公告)日： 2010-11-04
- 发明人: Akio Kayano , Mitsuo Nagai , Yorihisa Hoshino , Kazunori Wakasugi , Masaaki Matsuda , Atsushi Kamada , Minetaka Isomura , Yoshihiro Nishikawa , Seiji Yoshikawa , Daisuke Shimmyo
- 申请人： Akio Kayano , Mitsuo Nagai , Yorihisa Hoshino , Kazunori Wakasugi , Masaaki Matsuda , Atsushi Kamada , Minetaka Isomura , Yoshihiro Nishikawa , Seiji Yoshikawa , Daisuke Shimmyo
- 国际申请： PCT/JP2008/073513 WO 20081225
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D265/30
![PROCESS FOR PRODUCTION OF 4- (SUBSTITUTED PHENYL) HEXAHYDROPYRIDO [2,1-C] [1,4] OXAZIN-6-ONE](/abs-image/US/2010/11/04/US20100280243A1/abs.jpg.150x150.jpg)
摘要：
4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one represented by formula (I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an Aβ production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) or a salt thereof to an intramolecular condensation reaction.
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