发明申请
- 专利标题： PIG MODEL FOR PSORIASIS
- 专利标题（中）： PSORIASIS的PIG模型
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申请号： US12529812申请日： 2008-03-07
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公开(公告)号： US20100122356A1公开(公告)日： 2010-05-13
- 发明人: Peter Michael Kragh , Lars Axel Bolund , Karsten Kristiansen , Charlotte Brandt Sørensen , Jacob Giehm Mikkelsen , Nicklas Heine Staunstrup , Thomas Kongstad Petersen , Lars Svensson
- 申请人： Peter Michael Kragh , Lars Axel Bolund , Karsten Kristiansen , Charlotte Brandt Sørensen , Jacob Giehm Mikkelsen , Nicklas Heine Staunstrup , Thomas Kongstad Petersen , Lars Svensson
- 申请人地址： DK Aarhus C DK Ballerup DK Odense M
- 专利权人： AARHUS UNIVERSITET,LEO PHARMA A/S,SYDDANSK UNIVERSITET
- 当前专利权人： AARHUS UNIVERSITET,LEO PHARMA A/S,SYDDANSK UNIVERSITET
- 当前专利权人地址： DK Aarhus C DK Ballerup DK Odense M
- 优先权： DKPA200700343 20070307; DKPA200700362 20070308
- 国际申请： PCT/DK2008/050059 WO 20080307
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A01K67/027 ; C12N5/10 ; C12N15/63 ; A61P17/06
摘要：
The present invention relates to a genetically modified pig as a model for studying psoriasis. The modified pig model displays one or more phenotypes associated with psoriasis. Disclosed is also a modified pig comprising a mutation in the endogenous ILK-I Ra, JunB/cJun, CD18, IKK2, and/or LIG1 gene, and/or a human, porcine and/or murine PPARs, PPAR-δ, lκB-α, STAT3c, Integrin beta 1, Integrin alpha 2, MEK1, Amphiregulin, BMP-6, VEGF, JunBΔec-JunΔep, IL-I a, TGF.beta 1, CD18 hypo, Cre/lkk2FL/FL, Dsg1, SCCE, TGF-a, TNF-a, IL-20, IFN-g, LIG1 KO, KGF, IL-6, PAFR1 Cre/lkk2FL/FL, IL1 R, Dsg3, IFN-gamma, p40, ILI Ra, IKK2, JunB/c-Jun, and/or LIG1 gene, transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of psoriasis, for screening the efficacy of a pharmaceutical composition, and a method for treatment of human being suffering from psoriasis are disclosed.
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