Invention Application
US20100093652A1 Preservative System for Emulsion-Based Therapeutic Topical Formulations
审中-公开
基于乳液的治疗局部制剂的防腐剂系统
- Patent Title: Preservative System for Emulsion-Based Therapeutic Topical Formulations
- Patent Title (中): 基于乳液的治疗局部制剂的防腐剂系统
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Application No.: US12608345Application Date: 2009-10-29
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Publication No.: US20100093652A1Publication Date: 2010-04-15
- Inventor: Nicholas Spring , Edward J. Delaney
- Applicant: Nicholas Spring , Edward J. Delaney
- Applicant Address: US PA Horsham
- Assignee: Topaz Pharmaceuticals Inc.
- Current Assignee: Topaz Pharmaceuticals Inc.
- Current Assignee Address: US PA Horsham
- Main IPC: A61K31/7048
- IPC: A61K31/7048 ; A01N43/14 ; A01P1/00 ; A61P33/00

Abstract:
A topical formulation that inhibits the growth of microorganisms comprises an effective amount of an insecticide dissolved in an oil phase comprising a water-miscible or water-soluble surface active agent, a suspending agent, and a non-ionic surfactant, and an aqueous phase comprising one or more preservatives, where the aqueous phase is buffered to a specific pH. The overall antimicrobial efficacy in an emulsion formulation can be enhanced by buffering the aqueous phase of the emulsion to a pH at which the preservative system inhibits growth for a wider variety of microorganism types in the formulation relative to the equivalent formulation in which the aqueous phase is not buffered.
Information query