发明申请
- 专利标题： HCV NS-3 Serine Protease Inhibitors
- 专利标题（中）： HCV NS-3丝氨酸蛋白酶抑制剂
-
申请号： US12557638申请日： 2009-09-11
-
公开(公告)号： US20100003216A1公开(公告)日： 2010-01-07
- 发明人: Asa Rosenquist , Fredrik Thorstensson , Per-Ola Johansson , Ingemar Kvarnstrom , Susana Ayesa , Bjorn Classon , Laszlo Rakos , Bertil Samuelsson
- 申请人： Asa Rosenquist , Fredrik Thorstensson , Per-Ola Johansson , Ingemar Kvarnstrom , Susana Ayesa , Bjorn Classon , Laszlo Rakos , Bertil Samuelsson
- 申请人地址： SE Huddinge
- 专利权人： Medivir AB
- 当前专利权人： Medivir AB
- 当前专利权人地址： SE Huddinge
- 优先权： SE0400199-6 20040130; SE0401288-6 20040519; SE0402562-3 20041022
- 主分类号： A61K38/21
- IPC分类号： A61K38/21 ; A61K31/47 ; A61K38/06 ; A61P31/12
摘要：
Compounds of the formula where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
信息查询
IPC分类:
