The present invention discloses a multi-voltage headphone driver circuit comprising: at least one operational amplifier having an output supplied to a headphone speaker, the operational amplifier receiving a first power supply as its high operation voltage; a charge pump receiving a second power supply to generate a negative voltage corresponding to the second power supply in magnitude; and an m-fold circuit multiplying the negative voltage by m and providing the result to the operational amplifier as a low operation voltage thereof, wherein m is a real number.