发明申请
- 专利标题： Functional Mutations In Respiratory Syncytial Virus
- 专利标题（中）： 呼吸道合胞病毒中的功能突变
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申请号： US12241229申请日： 2008-09-30
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公开(公告)号： US20090117150A1公开(公告)日： 2009-05-07
- 发明人: Hong Jin , Robert Brazas , Bin Lu
- 申请人： Hong Jin , Robert Brazas , Bin Lu
- 申请人地址： US MD Gaithersburg
- 专利权人： MEDIMMUNE, LLC
- 当前专利权人： MEDIMMUNE, LLC
- 当前专利权人地址： US MD Gaithersburg
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C07K7/00 ; C12N15/11 ; C12N15/00
摘要：
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
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