Invention Application
- Patent Title: Functional Mutations In Respiratory Syncytial Virus
- Patent Title (中): 呼吸道合胞病毒中的功能突变
-
Application No.: US12241229Application Date: 2008-09-30
-
Publication No.: US20090117150A1Publication Date: 2009-05-07
- Inventor: Hong Jin , Robert Brazas , Bin Lu
- Applicant: Hong Jin , Robert Brazas , Bin Lu
- Applicant Address: US MD Gaithersburg
- Assignee: MEDIMMUNE, LLC
- Current Assignee: MEDIMMUNE, LLC
- Current Assignee Address: US MD Gaithersburg
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C07K7/00 ; C12N15/11 ; C12N15/00

Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Information query