Provided is a method of manufacturing a pneumatic tire, which is capable of reducing tire failure without leading to reduction in productivity, the method including: folding a cylindrical film made of thermoplastic resin or thermoplastic elastomer composition into a sheet shape; stacking rubber layers on both surfaces of the folded film in a manner that the rubber layers protrude from both edge portions of the film; forming a laminate by cutting protruding parts of the rubber layers into rubber protruding portions each having an amount of protrusion (h) in a range from 3 mm to 20 mm; expanding the laminate into a cylindrical shape and fitting the laminate onto a tire making drum; pressing down each rubber protruding portion toward the surface of the drum by use of a pressure roller; pasting other components of a tire onto the laminate to form an uncured tire; and curing the uncured tire.