Invention Application
US20080306242A1 INTERMEDIATES FOR LHRH ANTAGONIST SYNTHESIS, PROCESS FOR THE PRODUCTION, AND PROCESS FOR LHRH ANTAGONIST PRODUCTION
有权
LHRH拮抗剂合成的中间体，生产过程和LHRH拮抗剂生产过程
- Patent Title: INTERMEDIATES FOR LHRH ANTAGONIST SYNTHESIS, PROCESS FOR THE PRODUCTION, AND PROCESS FOR LHRH ANTAGONIST PRODUCTION
- Patent Title (中): LHRH拮抗剂合成的中间体，生产过程和LHRH拮抗剂生产过程
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Application No.: US12189925Application Date: 2008-08-12
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Publication No.: US20080306242A1Publication Date: 2008-12-11
- Inventor: Jon H. Rasmussen , Palle H. Rasmussen , Wolfgang O. Wachs , Stefan Hansen , Jens Fomsgaard
- Applicant: Jon H. Rasmussen , Palle H. Rasmussen , Wolfgang O. Wachs , Stefan Hansen , Jens Fomsgaard
- Applicant Address: DK Hillerod
- Assignee: POLYPEPTIDE LABORATORIES A/S
- Current Assignee: POLYPEPTIDE LABORATORIES A/S
- Current Assignee Address: DK Hillerod
- Priority: SESE0104463-5 20011229
- Main IPC: C07K7/23
- IPC: C07K7/23 ; C07K1/00 ; C07K5/00
Abstract:
The peptides Ac-D-2Nal-D-4ClPhe-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the heptapeptides P1-Ser(P2)-MMeTry(P3)-D-Lys(Nic)-Leu-Lys(iPr,P4)-Pro-D-AlaNH2 and P1-Ser(P2)-NMeTry(P3)-D-Asn-Leu-Lys(iPr,P4)-Pro-D-AlaNH2.
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