发明申请
US20080076790A1 CRYSTALLINE FORM OF 5(S)-(2-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN
失效
5（S） - （2'-羟基乙氧基）-20（S）-CAMPTOTHECIN的晶体形式
- 专利标题： CRYSTALLINE FORM OF 5(S)-(2-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN
- 专利标题（中）： 5（S） - （2'-羟基乙氧基）-20（S）-CAMPTOTHECIN的晶体形式
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申请号： US11753392申请日： 2007-05-24
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公开(公告)号： US20080076790A1公开(公告)日： 2008-03-27
- 发明人: Venkateswarlu Akella , Shanavas Alikunju , Ajaya Reka , Ramesh Mullangi , Raju Sirisilla , Subrahmanyam Duvvuri , Sriram Rajagopal
- 申请人： Venkateswarlu Akella , Shanavas Alikunju , Ajaya Reka , Ramesh Mullangi , Raju Sirisilla , Subrahmanyam Duvvuri , Sriram Rajagopal
- 申请人地址： IN Hyderabad 500 016 US NJ Bridgewater 08807
- 专利权人： DR. REDDY'S LABORATORIES LIMITED,DR. REDDY'S LABORATORIES, INC.
- 当前专利权人： DR. REDDY'S LABORATORIES LIMITED,DR. REDDY'S LABORATORIES, INC.
- 当前专利权人地址： IN Hyderabad 500 016 US NJ Bridgewater 08807
- 优先权： IN897/CHE/2006 20060524
- 主分类号： A61K31/436
- IPC分类号： A61K31/436 ; A61P35/00 ; C07D491/22
摘要：
A crystalline form of 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer of 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin is described that is characterized by having an X-ray powder diffraction pattern comprising one or more peak intensities expressed in degrees 2θ that are selected from the group consisting of 7.2±0.1, 9.4±0.1, 11.02±0.1, 12.00±0.1, 14.54±0.1, 15.2±0.1, 18.92±0.1, 21.86±0.1, 22.74±0.1 and 26.42±0.1. Methods of making and using the compound are also described.
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