Invention Application
US20080058369A1 Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors
失效
吡唑并[3,4-b]吡啶化合物及其作为PDE4抑制剂的用途
- Patent Title: Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors
- Patent Title (中): 吡唑并[3,4-b]吡啶化合物及其作为PDE4抑制剂的用途
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Application No.: US11831325Application Date: 2007-07-31
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Publication No.: US20080058369A1Publication Date: 2008-03-06
- Inventor: David Allen , Rodger Barnett , Reshma Chudasama , Caroline Day , Christopher Edlin , Leanda Kindon
- Applicant: David Allen , Rodger Barnett , Reshma Chudasama , Caroline Day , Christopher Edlin , Leanda Kindon
- Priority: GB0615286.2 20060801; GB0706790.3 20070405; GB0714815.8 20070730
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61P29/00 ; A61P37/08 ; C07D471/04
![Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors](/abs-image/US/2008/03/06/US20080058369A1/abs.jpg.150x150.jpg)
Abstract:
The invention provides N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-4-({8-[(2-hydroxyethyl)(methyl)amino]octanoyl}amino)benzamide, whose formula is , or a salt thereof, such as the monohydrochloride salt thereof. The invention also provides the use of the compound or salt as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, or rhinitis (e.g. allergic and/or non-allergic rhinitis).
Public/Granted literature
- US08003663B2 Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors Public/Granted day:2011-08-23
Information query
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