Invention Application
- Patent Title: SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, PHARMACEUITCAL COMPOSITIONS COMPRISING THEM AND THERAPEUTIC METHODS FOR THEIR USE
- Patent Title (中): 取代的4-苯基恶唑啉酮，包含它们的药物组合物及其使用的治疗方法
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Application No.: US11776041Application Date: 2007-07-11
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Publication No.: US20080058328A1Publication Date: 2008-03-06
- Inventor: Uwe HEINELT , Hans-Jochen LANG , Klaus WIRTH , Thomas LICHER , Armin HOFMEISTER
- Applicant: Uwe HEINELT , Hans-Jochen LANG , Klaus WIRTH , Thomas LICHER , Armin HOFMEISTER
- Applicant Address: DE Frankfurt
- Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
- Current Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
- Current Assignee Address: DE Frankfurt
- Priority: DE102005001411.9 20050112
- Main IPC: C07D217/12
- IPC: C07D217/12 ; A61K31/47 ; A61K31/5377 ; A61P13/00 ; C07D413/10 ; A61P25/00 ; A61P33/00 ; A61P9/00
Abstract:
The invention relates to substituted 4-phenyltetrahydroisoquinolines of formula I wherein R1-R8, N, W, X and Z are defined herein. These compounds and pharmaceutical compositions comprising them are useful in the treatment of respiratory disorders, sleep apnea, kidney disorders, high blood pressure, hypertension, disorders of the central nervous system and the like.
Public/Granted literature
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