发明申请
US20070066573A1 Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
失效
吡咯和吡唑衍生物作为谷氨酸受体的增效剂
- 专利标题： Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
- 专利标题（中）： 吡咯和吡唑衍生物作为谷氨酸受体的增效剂
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申请号： US10570985申请日： 2004-09-27
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公开(公告)号： US20070066573A1公开(公告)日： 2007-03-22
- 发明人: Pamela Albaugh , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang , Paul Ornstein , Michelle Thompson , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman , Ana Castano Mansanet , Larry Huffman , William Miller
- 申请人： Pamela Albaugh , Esteban Dominguez-Manzanares , Jian Hong , William Hornback , Delu Jiang , Paul Ornstein , Michelle Thompson , Eric Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Zimmerman , Ana Castano Mansanet , Larry Huffman , William Miller
- 优先权： EP3380224.0 20031008
- 国际申请： PCT/US04/28815 WO 20040927
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; A61K31/433 ; A61K31/4196 ; A61K31/42 ; A61K31/425 ; A61K31/415 ; A61K31/416 ; A61K31/4025 ; A61K31/401 ; C07D417/02 ; C07D413/02 ; C07D405/02 ; C07D403/02
摘要：
The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
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