发明申请
US20050272761A1 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
失效
7-氮杂吲哚作为用于治疗神经变性疾病的c-jun N-末端激酶的抑制剂
- 专利标题： 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
- 专利标题（中）： 7-氮杂吲哚作为用于治疗神经变性疾病的c-jun N-末端激酶的抑制剂
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申请号： US10509128申请日： 2003-03-17
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公开(公告)号： US20050272761A1公开(公告)日： 2005-12-08
- 发明人: Piotr Graczyk , Hirotoshi Numata , Afzal Khan , Vanessa Palmer
- 申请人： Piotr Graczyk , Hirotoshi Numata , Afzal Khan , Vanessa Palmer
- 申请人地址： JP Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 优先权： GB0207491.2 20020328; GB0217330.0 20020725
- 国际申请： PCT/GB03/01112 WO 20030317
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61P1/04 ; A61P1/16 ; A61P1/18 ; A61P3/00 ; A61P3/08 ; A61P3/10 ; A61P7/00 ; A61P7/02 ; A61P7/04 ; A61P7/06 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P11/02 ; A61P11/06 ; A61P13/02 ; A61P13/12 ; A61P17/04 ; A61P19/08 ; A61P21/04 ; A61P25/00 ; A61P25/08 ; A61P25/14 ; A61P25/16 ; A61P25/28 ; A61P29/00 ; A61P31/00 ; A61P31/18 ; A61P35/00 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07B61/00 ; C07D471/04 ; C07D471/02 ; A61K31/4745
摘要：
The present invention relates to novel 3,5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medecine and particularly in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation. The invention also provides processes for manufacture of said compounds, compositions containing them and processes for manufacturing such compositions.
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