An opening and closing body control device includes an actuation device for actuating an opening and closing body which operates relative to a body, a speed detection device for detecting moving speed of the opening and closing body, and a control device for driving the actuation device based on detected results from the speed detection device. The control device conducts anti-pinch transaction when an object is pinched between the opening and closing body and the body. The control device includes a speed difference calculation device for calculating speed difference between latest speed and speed at predetermined time earlier, a speed difference memory device for memorizing predetermined number of the speed differences, an accumulation device for calculating accumulation value by accumulating predetermined number of speed differences, and a pinch detection device for conducting anti-pinch transaction by comparing the accumulation value and reference value for occurrence of pinch.