发明申请
- 专利标题： Spatially-defined macrocycles incorporating peptide bond surrogates
- 专利标题（中）： 引入肽键代用品的空间定义大环
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申请号： US10911219申请日： 2004-08-02
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公开(公告)号： US20050119169A1公开(公告)日： 2005-06-02
- 发明人: Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark Peterson , Hamid Hoveyda , Sylvie Beaubien , Eric Marsault
- 申请人： Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark Peterson , Hamid Hoveyda , Sylvie Beaubien , Eric Marsault
- 申请人地址： CA Sherbrooke
- 专利权人： TRANZYME PHARMA INC.
- 当前专利权人： TRANZYME PHARMA INC.
- 当前专利权人地址： CA Sherbrooke
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; C07D491/02 ; C07K1/04 ; C07K5/00 ; C07K5/08
摘要：
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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