知搜-全球专利检索

  1. 登录
  2. 注册
发明申请
US20050014818A1 Process for producing optically active chroman derivative and intermediate 审中-公开
光学活性苯并二氢吡喃衍生物和中间体的制备方法

Process for producing optically active chroman derivative and intermediate
摘要：
A process for easily producing various optically active chroman derivatives that are useful as pharmaceutical intermediates from inexpensive starting materials is provided. Cyclic hemiacetal (1) obtained from dihydrocoumarin through one step is asymmetrically reduced to produce an optically active halohydrin derivative (3), and the optically active halohydrin derivative (3) is cyclized to produce an optically active chroman derivative (13):
摘要（中）：

提供了一种易于制备可用作廉价起始材料的药物中间体的各种光学活性苯并二氢吡喃衍生物的方法。 通过一步从二氢香豆素获得的环状半缩醛（1）被不对称地还原以产生光学活性的卤代醇衍生物（3），并将光学活性卤代醇衍生物（3）环化以产生光学活性苯并二氢吡喃衍生物（13）：

信息查询
Global Dossier Espacenet
0/0