发明申请
- 专利标题： (2S, 3S) -2,3-butanediol dehydrogenase
- 专利标题（中）： （2S，3S）-2,3-丁二醇脱氢酶
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申请号： US10858707申请日： 2004-06-02
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公开(公告)号： US20050003500A1公开(公告)日： 2005-01-06
- 发明人: Masatake Kudoh , Hiroaki Yamamoto
- 申请人： Masatake Kudoh , Hiroaki Yamamoto
- 申请人地址： JP Osaka
- 专利权人： Daicel Chemical Industries, Ltd.
- 当前专利权人： Daicel Chemical Industries, Ltd.
- 当前专利权人地址： JP Osaka
- 优先权： JP2003-162872 20030606
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C07B53/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N9/04 ; C12P7/16 ; C12P7/18 ; C12P41/00 ; C12R1/01
摘要：
An objective of the present invention is to produce a novel (2S,3S)-2,3-butanediol dehydrogenase useful for the production of ketones, alcohols, and particularly optically active vicinal diols. Zoogloea ramigera has been found to produce a novel (2S,3S)-2,3-butanediol dehydrogenase having high activity and high stereoselectivity. Furthermore, a DNA chain encoding this (2S,3S)-2,3-butanediol dehydrogenase was cloned and the nucleotide sequence thereof was determined. The expression of the (2S,3S)-2,3-butanediol dehydrogenase was carried out in a heterologous microorganism.
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