- 专利标题： Modulators of liver receptor homologue 1 (LRH-1) and uses
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申请号： US18200431申请日： 2023-05-22
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公开(公告)号： US12065402B2公开(公告)日： 2024-08-20
- 发明人: Eric Ortlund , Suzanne Mays , Nathan Jui , Autumn Flynn , Michael Dugan
- 申请人： Emory University
- 申请人地址： US GA Atlanta
- 专利权人： EMORY UNIVERSITY
- 当前专利权人： EMORY UNIVERSITY
- 当前专利权人地址： US GA Atlanta
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 分案原申请号： US16495092
- 主分类号： C07C59/54
- IPC分类号： C07C59/54 ; C07C35/50 ; C07C39/23 ; C07C43/23 ; C07C49/683 ; C07C49/83 ; C07C215/70 ; C07C255/47 ; C07C271/34 ; C07C307/02 ; C07C309/66 ; C07D249/04 ; C07F9/09 ; C07F9/572
摘要：
This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.
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