Various technologies described herein pertain to active noise cancellation in the interior of a vehicle. In exemplary embodiments, a microphone mounted on the vehicle outputs an audio signal indicative of noise emitted by a noise source. A computing system of the vehicle determines a position of the noise source based upon sensor signals output by sensors mounted on the vehicle. The computing system further determines a position of a passenger in the vehicle based upon a sensor mounted inside the vehicle. The computing system generates a complementary signal that is configured to attenuate the noise based upon the audio signal, the position of the noise source, and the position of the passenger. The complementary signal is then output by way of a speaker in the interior of the vehicle.